Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex


Structural Membrane Biology

The interplay between proteins and membrane lipids is central to almost every aspect of cell biology. This laboratory is interested in fundamental questions of how the interactions between proteins and membranes determine cell and organelle shape and the evolution of shape over time, how protein-membrane interactions turn on and off the signals that control essential cell processes, and how pathogens such as HIV-1 subvert and co-opt these interactions.

The lab philosophy is to use a battery of powerful approaches to uncover molecular mechanism. This might mean cryoelectron microscopy, x-ray crystallography, single molecule spectroscopy, mass spectrometry, biochemical reconstitution, or live-cell imaging. We do it all. Training in the Hurley lab entails both a buy-in to our interdisciplinary approach and mastery of at least two different major technical disciplines.


Follow the Research link for details on individual projects in the lab.


BBS and CDB divisions